Abstract： Objective To investgate the value of Fuji Intelligent Chromo Endoscopy(FICE) for the diagnosis of colonrectal neoplasia. Methods 781 patients were examined with ordinary colonoscopy from Janury in 2009 to February in 2010. 236 patients with colon neoplasm or polypoid lesion were enrolled in this study. The patients were examined with magnifying conventional colonoscopy, magnifying FICE technique and magnifying chromoendoscopy technique, the pit pattern and blood capillary form of the lesion were examined. The endoscopic diagnosis was made,and compared with pathologic diagnosis. Results 431 neoplasms were detected in the 236 patients,among those 91.0% were detected with magnifying conventional endoscopy,97.9% were detected with FICE technique, there was significant difference between the two methods. FICE could more clearly show the structure and form of mucosal blood capillary than chromoendoscopy technique, ( P ＜ 0. 01 ) , there was no significant difference between the two methods for showing the pit pattern. The coincident rate of FICE for the diagnosis of tumor and non-tumor lesions was 90.7% ,which was significant higher than that of chromoendoscopy 82.3% (P ＜ 0. 01 ). Conclusion Magnifying FICE endoscopy could show mucosal microstructure and blood capillary form. It has the superiority of high coincident rate in distinguishing neoplastic from non-neoplastic colorectal lesions compared with conventional magnifying colonoscopy and magnifying chromoendoscopy. The detected rate of early carcinoma of colon is dramatically increased with FICE. FICE could be easily operated, and have satisfactory clinical practical value