Abstract： Objective To observe the sedation effect of propofol used in the serious patients in neurosurgery.Methods 36 patients with fidget and falling sickness who have no effect with general therapy were seleeted.Propofol was injected persistence.Then registed and analysed the results.Results 28 cases obtained salience effect.Total 34 cases had the effect.Total efficiency was 94.45 %.it had shown satatistically significant and is took effect qnikly and dppd effect and higher security.Conclusion We have obtained salience effect with propofol.Propofol is a excellence medicine in the therapy of the patients with fidget.