Discussion operation and treated therapy on gastrointestinal stromal tumour patients

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Author:
WANG Ben-yi(Depantmont of Goneral Surgery Xinyang The first people's Hospital Xinyang 464000,China)
LI Fang-lie(Depantmont of Goneral Surgery Xinyang The first people's Hospital Xinyang 464000,China)
FENG Yuan-yuan(Depantmont of Goneral Surgery Xinyang The first people's Hospital Xinyang 464000,China)
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
Volume 04, Issue 05, 2010
DOI:
10.3760/cma.j.issn 1673-8799.2010.05.52
Key Word:
Gastrointestinal stromal tumor;Operation;Targeted therapy

Abstract: Objective To explor quality surgery,cell of tumour excise with molecule target to the clinical result that is treated probe into intestines and stomach malignant. Methods Our hospital were retrospectively analyzed 16 patients admitted 2000-2007 gastrointestinal stromal cell tumor surgery and targeted therapy in cases of information. Results Surgery and no perioperative deaths and no serious postoperative complications occurred. 11 cases of radical surgery in 3-year survival in 9 cases (9/11), 5-year survival of 5 cases (5/11). 6 cases of postoperative oral administration of imatinib mesylate (Imatinib) receiving targeted therapy, (radical surgery in 2 cases,4 cases of non-radical surgery, of which 1 case was re-surgery). Re-operation were intra-abdominal GIST, for the first time in November when postoperative bowel obstruction symptoms, the re-operation for local recurrence and the formation of adhesions,line side to side anastomosis, after oral administration of imatinib had a good life. Non-radical surgey in 2 cases without targeted therapy and chemotherapy, died in 18 months,23 months ofter operation. All of the survival of good quality targeted therapy. Conclusion ①gastrointestinal stromal tumor(gastrointestinal stromal tumor GIST)is the source of fat in the gastrointestinal non-epithelial tumors,mesenchymal tumors belong to the digestive tract. ②The treatment of first surgery, the first time, radical surgery must be to achieve the goal. During surgery tend to have more visceral resection. Second, the molecular targeted therapy imatinib mesylate(Imatinib mesylate) treatment of GIST is a successful example of targeted therapy is the treatment of tumors reflects the molecular level. (3) radical surgery + targeted therapy for GIST treatment, the cancer treatment is the best combination and Whether it can greatly improve the clinical results, need to continue to observe. Imatinib mesylate(Imatinib mesylate)-resistant with alternative products.

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