Relationship between the IMT of common carotidartery and the serum level of HMGB1 in patients with cerebral infarction
- Author:
- No author available
- Journal Title:
- CHINA CLINICAL PRACTICAL MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn1673-8799.2010.05.39
- Key Word:
- 脑梗死;高迁移率蛋白-1;颈动脉;内膜-中层厚度;Cerebral infarction;Highmobility groupbox-1 (HMGB1);Carotidartery;Intima-media thickness (IMT)
Abstract： Objective To investigate the relationship between the intima-media thickness (IMT)of common carotidartery and the serum level of HMGB1 in patients with cerebral infarction.Methods The IMT of carotidartery were assessed by high resolution Doppler ultrasonography in 104 patients with with cerebral infarction and 60 healthy controls,and the serum HMGB1 was measured using ELISA,compared with those in 60 healthy subjects.Results The levels of the intima-media thickness (IMT) of common carotidartery and serum HMGB1 of patients with cerebral infarction were markedly higher than those in the control groups.There was an obvious relationship between the intima-media thickness (IMT) of common carotidartery and the level of serum HMGB1 (r = 0.64 ,P ＜ 0.01).Conclusion The level of serum HMGB1 and the intima-media thickness(IMT)of common carotidartery had instructive significance in acute cerebral infarction treating and prognosis estimating.
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