Abstract： Objective To study the relationship between allergic purpura and Helicobacter pylori infection and direct therapy.Methods From December 2007 to December 2009 120 cases at the undergraduate treated of HSP patients had HP-IgG antibody been tested,and serum Hp-IgG-positive patients were randomly divided into two groups,A group on the basis of conventional therapy to give anti-Hp therapy,B group only conventional treatment,cured patients were followed up for 6 months.Results 120 case with The percentage of HpIgG-positive is 67.5% ,Hp-IgG-positive HSP patients given conventional therapy on the basis of anti-Hp therapy,there are high efficiency and low recurrence rate.Conclusion Helicobacter pylori infection in the pathogenesis of allergic purpura is one important factor,anti-HP therapy is conducive to the rehabilitation of HSP.