Abstract： Objective To investigate glucose metabolism and insulin resistance in the adult women with polycystic ovary syndrome(PCOS).Methods Seventy-eight cases of obese women witb PCOS,ninety cases of non-obese women with PCOS and one hundred cases of control group were reviewed regarding clinical features,endocrinal hormone,fasting glucose,fasting insulin,2 h postprandial glucose and 2 h postprandial insulin.Results The menstrual cycle,Hirsutism,acne,ultrasonography suggested ovarian increase,polycystic ovary change and infertility of adult women with PCOS were significantly different compared with the control group(P ＜ 0.05).And the fasting glucose,2 h postprandial glucose,fasting insulin,2 h postprandial insulin of the obese group were also significantly higher compared with the control group (P ＜ 0.05).Conclusion Attention would be paid to patients with early oligomenorrhea and high BMI for PCOS diagnosis.Adult women with PCOS especially the obese should check abnormal glucose metabolism and insulin resistance to determine whether actions should be taken to avoid the menace of long term complication.