Abstract： Objective To explore the changes of TXA2,PGI1 and hepatic function as well as effects of salvia miltiorrhiza on the patiente with server acute pancreatitis hepatic injury. Methods 57 patitnts with SAP were randomly divided ito control group and salvia miltiorrhiza treatment group. Patientes in control group received routine treatment, and the patients in salvia miltiorrhiza treatment group received additional salvia miltiorrhiza. The changes of plasma TXA2, PGI1 and hepatic function were conitored and compared between them. Results Plasma TXA2, the ratio of TXA2/PGI1 were significantly lower in the salvia miltiorrhiza group as compared with the control group on the 3,7,14 d after treatment( P ＜ 0.05 or P ＜ 0.01 ) ;but there were no obvious difference in the plasma PGI1 levels at each time point. The hepatic function in the salvia miltiorrhiza group were change normal after 14 days,which had signification difference than those in the control gruop P ＜ 0.05orP ＜0.01). Conclusion The salvia miltiorrhiza had a significant efficacy to treated the SAP hepatic injure. salvia miltiorrhiza may correct the imbalance between constrictionand factor and relaxation factor to improve the microcirculation of hepatic, and this was one of the mechanisms of salvia miltiorrhiza in treatment of SAP hepatic injure.