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The clinical study of combined Hemoperfusion+hemodialsi in chronic renal failure

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
11
DOI:
10.3760/cma.j.issn1673-8799.2009.11.04
Key Word:
血液灌流;血液透析;慢性肾功能衰竭;中分子毒素;Hemoperfion;Hemodialysis;Chronic renal failure;Middle molecuular substances

Abstract: Objective To investigate the effect and safety of combined hemodialysis-resin hemoperf usion in chroicuremia.Methods 34 pailnets with chronic uremia were treated by combined hemodialysis-resin hemoperfusion.Middle molecular substances(MMS),urea and creatinine were detcted before and after the treatment.Meanwhile.we compared the effect of combined hemodialysis-resin hemoperfusion procdure with conventional hemodialysis in uremic toxin clearance.Results MMS was reduced significantly in combined hemodialysis-hemoperfusion procedure(P<0.01).Compared with conventional hemoodialysis,a combination of hemoperfusion and hemodialysis had a better effect in MMS clearance(P<0.01).Meanwhile,some clinical conditions (appetite,pruritus,insomnia)improved.we did not found any adverse effect.Conclusion as a method of MMS clearance,resin hemoperfusion Can effectively clean MMS and WaS confirmed to be a safand risk-free procedare.

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