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The clinic features and the short-term efficacy of antiviral treatment on patients with HBeAg negative chronic severe hepatitis B

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
11
DOI:
10.3760/cma.j.issn1673-8799.2009.11.01
Key Word:
肝炎;乙型;慢性;e抗原;肝功能衰竭;抗病毒治疗;Hepatitis B;Chronic;Hepatitis B e antigens;Liver failure;Antiviral therapy

Abstract: Objective To investigate the clinic features and the short-term efficacy of antiviral treatment on pafients with HBeAg negative chronic severe hepatitis B.Methods 252 HBeAg negative and 100 HBeAg positive Patients with chronic severe hepatitis B were rolled.The patients were divided into two groups,one was with antiviral therapy(LAM or Etv or Ltd)and routine supportive therapy,and the control group received supportive therapy only.The clinical features and the short-term(24 weeks)efficacy of antiviral therapy were compared.Resuits The age,total bilirubin and the incidence rates of hepatic encephalopathy and spontaneous peritonitis of HBeAg negative patients were significantly higher,otherwise the alanine aminotransferase,aspartate aminotransferase and the viral load were lower.There wag no significant difference in the mortality between the HBeAg negarive and HbeAg positive patients(P>0.05).The survival rate of patients in the antiviral therapy group was higher than that in control group of the HBeAg negative patients(P<0.05).Conclusion There was difference in the clinic features between the HbeAg negative and HBeAg positive patients with chronic severe hepatitis B.The antiviral therapy significantly improves survival rate of patients of the HBeAg negative patients.

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