Abstract： Objective To find out risk factors of traumatic cerebral infarction(TCI). Methods 126 cases in severe craniocerebral trauma were analyzed, risk factors of TCI were screened by single factor and Logis-tic regression analysis. Results TCI was found in 47 patients. There was significant difference on low blood pressure, contusion and laceration of brain, subarachnoid hemorrhage, brain herniation, duration of low blood pressure, duration of brain herniation, DM(or duration of blood glucose more than11.1 mmol/L≥24 h), dura-tion of mechanical ventilation after trauma or operation <48 h between TCI group and non-TCI group (P<0.05), Logistic regression analysis of them indicated that contusion and laceration of brain, duration of mechani-cal ventilation after trauma or operation <48 h, duration of low blood pressure, duration of brain hernia were in-dependent risk factors. Conclusion The contusion and laceration of brain, duration of mechanical ventilation after trauma or operation <48 h,low blood pressure and its duration, brain herniation and its duration, subarach-noid hemorrhage, DM (or duration of blood glucose more than11.1 mmol/L≥24 h)were the risk factors of TCI, and the contusion and laceration of brain, duration of mechanical ventilation after trauma or operation <48 h, du-ration of low blood pressure, duration of brain hernia were independent risk factors.