Abstract： Objective To evaluate the clinical effect of the combined therapy with bladder preservation for patients with invasive bladder cancer. Methods 74 cases of invasive bladder cancer patients of different sta-ges and grades were divided into two groups randomly. The 42 patients of control group received radical bladder cystectomy, while the 32 patients of the combined therapy group implemented twice intra-artery infusion chemo-therapy before the operation of partial cystectomy or TUR-Bt and bladder infusion chemotherapy postoperatively. All the patients were followed up for 5 years, and the survival rate of the two groups was compared. Results The 5 years survival rate were 61.9% and 56.3% in the control group and the combined therapy group respectively, there was no significant difference between the two groups (P>0.05). Conclusion The combined therapy with bladder preservation for invasive bladder cancer was an effective way to cure invasive bladder cancer.