Abstract: Objective To study the the method of improving clinical efficacy and the living quality by using DDP with IL-2 to cure the malignant ascites of digestive tract. Methods 30 samples of cancer aseitos are radomly seperatod to the treatment group and the control group. The procedures for the treatment group are given DDP for che migical treatment at the first week and then given IL-2 at the second week. While the procedure for control group is given only DDP for chemical treatment for 3 weeks continuously. Results The total efficacy of the treatment group is 66. 67%. The total efficacy of the control group is 46. 67%. The improvement of living quality of the treatment group is 86. 67%. The improvement of living quality of the control group is 66. 67%. There are signifieant difference between the two groups. (P < 0. 05 ). Conclusions Compared with only DDP, using DDP with IL-2 to eure the cancer aacites can improve the clinical efficacy, while lowering the influence of immune system and the toxic side effects by chemical treatment, with the improvement of living quality of pa-tients. DDP sequentd IL-2 can be used as a effective method of curing malignant aacites.