Abstract： Objective To determine the diagnosis of measurement of macular thickness with optical cohercnce tomography(OCT) in glaucoma.Methods OCT was used to measure the macular thickness in 60 eyes of 42 normal persons and 66 eyes of 43 patients with glaucoma.Observing the image feature of macular thickness mapping in normal persons and glaucoma patients comparing the macular thickness between both groups,finding the strongest discriminating power parameter for glaucoma detection by area under the receive operator characteristic curve.Results The macular thickness mapping in normal persons was"house shoe" shaped.Diffuse on local thinning of macular thickness was shown in glaucoma patients.All macular parameters were statistically signifieantly different compared with normal subjects and glaucoma(P＜0.05).Macular outer ring in four quadrants,total macular volume were statistically significantly different comparing normal subjects and early glaucoma (P＜0.05).The highest AROC was maeular inferior outer ring between normal persons and slaucoma patients (0.881 and 0.719 respectively).Conclusion Measurement of macular thickness with OCT is effective in early diagnosis of glaucoma.