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The effects of ligustrazine on red cells by intraoperative blood salvage and the changes in blood coagulation

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
12
DOI:
No doi available
Key Word:
输血;自体;川芎嗪;红细胞;血液凝固;Blood transfusion;Autologous;Ligustrazine;Red cell;Blood coagulation

Abstract: Objective To investigate the effects on the red cell of the intraopertive blood salvage by li-gustrazine and the changes in blood coagulation after reinfusion ,on the basis of which to evaluate the value of re-trieval rate of red cell by ligustrazine. Methods Forty ASA Ⅰ~Ⅱ patients undergoing elective lumbar surgery were randomly divided into two groups. In study group, ligustrazine had been injected intravenously to the pa-tients 30 min before their blood was collected. And ligustrazine was put into the washing saline and heparinized saline. Shed blood of both groups were collected, filtrated, separated and washed before reinfusion to the pa-tients. Then the retrieval rate of red cell was calculated according to formula. Hemoglobin (Hb), hematocrit (HCT), platelet count(PLT), prothrombin time (PT), activated partial thromboplastin time (AFFr)and plasma fibrinogen concentration(FiB)of the samples were determined in such phases as before operation,after blood transfusion and 24 h after operation, respectively. Thromboelastography (TEG) was counted before operation and after reinfusion. As the negative control, no ligustrazine was put into the washing saline and heparinized and no ligustrazine was injected to the patients. Results In study group, the retrieval rate was markedly higher than the control group. In two groups, after reinfusion, Hb, HCT, PLT, FIB concentration and maxium amlitude (MA) de-creased significantly, but PT, APTT and reaction time (R) prolonged significantly. But the two groups show the same tendency of the parameter varieties. Conclusion Ligustrazine can increase the retrieval rate of red cell. And there was no significant difference on coagulation compared with the control group after reinfusion.

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