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Significant study on the protein expression of IFN-γ in anaphylactic shock

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
11
DOI:
No doi available
Key Word:
过敏性休克;干扰素-γ;病理生理;Allergic shock;IFN-γ;Pathophysiology

Abstract: Objective To investigate the changes of protein expression levels of IFN-γ in the heart,lungs,kidney,liver and spleen from patients who died of allergic shock to discuss the possible mechanism of allergic shock in vivo.Methods Twelve casel who died of allergic shock confirmed by autopsy and histologie examination performed by verification centre of forensic medicine of Sun Yat-sen university from Feb.2006 to Oct,2007 were enrolled,including 7 males and 5 females aging from 3~65 years.Tissues from heart,lung,kidney.liver and spleen were taken.Samples from the same organs of fifteen healthy cases died of accidence were taken as normal control,including 8 males and 7 females aging from 12~55 years.Histochemistry was used to determine the protein expression site of IFN-γ in the tissues.Image analysis system and statistical methods were used to compare the photedensity and positive cell numbers.Statistical analysis was performed using SPSS software paeknge.Results In the allergic shock group,tissue sections showed widely distributed congestion in all organs,interstitial vessel congestion,eosinophile granulocytes in lungs,partial hyalinization or fibrosis of renal glomeruli.slight autolysis of epithelia of renal tubules and fatty degeneration of a portion of hepatic cells.The protein levels of IFN-γ in all organs of the cases in the allergic shock group were both higher than those in the normal control group(P<0.05),The differences were of statistical significance.Conclusion The present study suggesting that IFN-γ may be involved in the regulation of development of allergic shock.

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