Abstract: Objective To investigate the effect of articular cavity flushing operation and intra-articular injection of Triamcinolone Acetonide and sodium hyaluronate for osteoarthristis of knee.MethodsNS 1500~ 2500 ml and 20% Mannitol In jeetion 250 ml flushing articular cavity with NS 1500~ 2500 ml and 20% Mannitol In jection 250 ml.After flushing articular cavity,articular cavity was injected Triamcinolone Acetonide 5 mgonce a week for 3 weeks.Articular cavity was injected sodium hyaluronate 2.5 ml once a week for 5 weeks from the 3rd day after the last operation,then sodium hyaluronate 2.5 ml was injected every three months.Results After 13-25 months follow-up,the efficiency was 90.2% and the total effective rate was 96.8%.Conclusion Articular cavity flushing operation and intra-articular injection of Triamcinolone Acetonide and sodium hyaluronate for osteoarthristis of knee is a safe and effective method.