Depression of the multi-channel EEG sleep study

( views:308, downloads:0 )
ZHENG Hao(Department of Neurology,Guangzhou No.1 People's Hospital,Guangdong 510080,China)
LI Ze(Department of Neurology,Guangzhou No.1 People's Hospital,Guangdong 510080,China)
PAN Xiao-ping(Department of Neurology,Guangzhou No.1 People's Hospital,Guangdong 510080,China)
Journal Title:
Volume 2, Issue 07, 2008
Key Word:
Depression;Polysomnography;Repid eye movement

Abstract: Objective To abyss the changes on the whole night polysomnography(PSG)in patients with depression disorder and study the difference between patients and normal subjects.Methods The whole night PSG was recorded from 20 patients with depression,and 20 normal subjects with sleep instrument.Results Compared with normal subjects,depression patients have prolonged incubative stage of sleep,reduced sleep maintenance,reduced slow wave sleep and increased density of REM.Conclusion We consider that the depression patients usually fall asleep difficulty,easy to awake,or awake earlier.The characteristic changes of polysomnography in depression patients are the overacfivity of the BEM sleep.The incubative stage of REM sleep reduced andthe density of REM increased.The reasonmay be the reduce of the 5-HT/NE transmission and the increave of cholinergic transmission.We consider that the characteristic changes of REM sleep in depression patients have important clinical significance as the evidence of the diagnosis of depression.

  • [1]郭克锋.关菊香.抑郁症患者睡眠障碍与康复的关系研究.中国临床康复,2002,6(7):952-953.
  • [2]Rechtschaffen A,Kaless A.A manual of standardized terminology,techniques and scoring system for sleep stages of human sleep subjects.Washington,DC:U.S.Government Printing Office,1968.
  • [3]潘小平,尹平,何方红,等.综合性医院心理咨询515例分析.中国现代医学杂志,2001,11(4):61-62.
  • [4]Buysso DJ.1nsomia,depression and aging.Assessing sleep and mood interactions in older adults.Geriatrics,2004,59(2):47-51,quit 52.
  • [5]Patricia P,Chang,Daniel E,Ford,Lucy A,et al.Insomnia in young men and subsequent depression:The Johns Hopkins PrecursorsStudy.American journal of epidemiology,1997,146:105-114.
  • [6]Riqu DJ.Thaso EM.Treatment of Insomnia associated with Clinical Depression.Sleep Medicine,2004:8:19-30.
  • [7]Kupfer DJ,Monk TH,Barchas JD.Biologieal rhythms and mental disorders.New York:Guiford Press,1988:11-19.
  • [8]Toussaint M,Luthringer R,Starter L,et al.Changes in EEG power density during sleep laboratory adaptation in depressed inpatients.Biol Psychiatry,2000,47:626-633.
  • [9]侯钢,张心保,耿直,等.抑郁症患者REM睡眠研究.临床精神医学杂志,1999,9(1):4-6.
  • [10]Dykierrk P,Stadtmuller G,Schramm P,et al.The value of REM sleep parameters in differentiating.Alzheimer's disease from oldage depression and normal aging.J Psychiatr Res,1998,32(1):1-9.
  • [11]赵忠新.临床睡眠障碍学.第二军医大学出版社,2003:12.
  • [12]Seifaitz E,Gillin JC,Rapaport MH,et al.Sleep electroencephalographic response to mnscarinic and sorotonin 1A receptor probes in patients with major depression and in normal controls.Bid Psychiatry,1998,44:21-33.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615