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Clinical value of the measuring the level of serum leptin in patients with chronic hepatitis B incorporate alcoholic liver disease

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Author:
No author available
Journal Title:
CHINA CLINICAL PRACTICAL MEDICINE
Issue:
1
DOI:
No doi available
Key Word:
酒精性肝病;慢性乙型肝炎;瘦素;胰岛素抵抗;Alcoholic liver disease;Chronic hepatitis B;Leptin;Insulin resistance

Abstract: Objective To determine serum leptin levels in chronic hepatitis B incorporate alcoholic liv-er disease (CHB + ALD),and investigate its relationship between insulin resistance in CHB + ALD patients.Methods 17 male patients with CHB + ALD,15 male patients with cirrhosis of liver, 19 male patients chronic hepatitis B ,and 12 male healthy control were enrolled in this study,matched for gender,age and body mass in-dex (BMI). The level of leptin was measured by ELISA. Fasting glucose, blood lipid, insulin levels, liver func-tion and renal function were determined. Height,weight and BMI were also measured. Results Serum leptin levels in CHB + ALD and cirrhosis of liver were significantly higher than those of healthy control(P<0.05).There was no significant difference of the chronic hepatitis B patients(P>0.05). Serum leptin levels in CHB +ALD were significantly correlated with BMI,insulin,respectively(r=0.169,0.267, P<0.05). There were sig-nificant negative correlations both between serum leptin and triglycerides (TG) (r=-0.249, P<0.05). Con-clusion Serum leptin levels height markedly in CHB + ALD,and relationship with higher insulin levels and in-sulin resistance. The expression of leptin is not relative to the severity in chronic hepatitis.

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