Abstract: Objective To probe the value of hyperechogenic area to predict ablated area during radio-frequency ablation(RFA) of malignant hepatic tumor. Methods The maximum transverse diameter of hypere-chogenicity(D1) on conventional ultrasonogram and the maximum transverse diameter of no-enhanced zone on Contrast-enhanced uhrasonogram(D2) were measured at the same scan plane in 50 with RFA treatment. Results There was high linear relationship between D1 and D2 (r=0.971, P<0.001). The regression equation was D2=0.279+0.988 D1. The D1 and D2 were considered highly consistent. Conclusion The monitoring of the hy-perechogenicity during RFA in patients with malignant hepatic tumors can predict the coagulation area and might be helpful to prevent the ablation of adjacent organs and vessels.