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Oral use of GAD65 Porotein delays the onset of type Ⅰ diabetes mellitus in non-obese diabetic mice
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- Author:
- No author available
- Journal Title:
- CHINA CLINICAL PRACTICAL MEDICINE
- Issue:
- 7
- DOI:
- No doi available
- Key Word:
- 重组GAD65蛋白;Ⅰ型糖尿病;NOD小鼠
Abstract： 目的 研究重组GAD65蛋白对NOD小鼠Ⅰ型糖尿病的预防作用.方法 6周龄NOD雌鼠3次/周灌胃重组GAD65蛋白,共6～56周,观测胰岛炎和糖尿病发病情况.结果 重组GAD65蛋白能明显降低NOD小鼠糖尿病的发生和胰岛炎的严重程度.结论 口服重组GAD65蛋白能预防NOD鼠糖尿病.
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