Clinical analysis of 11 patients with reversible posterior leukoencephalopathy syndrome

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LIU Kun(Department of Neurology, the Eighth People's Hospital of Qingdao, Qingdao, Shandong 266100, China)
SU Wen-wen(Department of Neurology, the Eighth People's Hospital of Qingdao, Qingdao, Shandong 266100, China)
YU Dun-bo(Department of Neurology, the Eighth People's Hospital of Qingdao, Qingdao, Shandong 266100, China)
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Volume 19, Issue 20, 2012
Key Word:
Leukoencephalopathy, progressive multifocal; Meta-analysis

Abstract: Objective To explore the clinical characteristics of reversible posterior leukoencephalopathy syndrome ( RPLS ),in order to deepen the awareness of the disease.Methods The clinical data of 11 patients with RPLS in our hospital were retrospectively analyzed.Results In the 11 cases with RPLS,there were two cases of pregnancy induced hypertension,preeclampsia(38 weeks pregnant),four eases of chronic renal insufficiency,four cases of malignant hypertension,and one case of lung cancer after chemotherapy.The main clinical presentations were headache,abnormality of visual perception,mental and behavioral abnormalities,ataxia,epileptic seizure and so on.The neuroimaging performances were extensive white matter abnormalities of the rear of the bilateral cerebral hemispheres,such as the parietal-occipital temporal lobe lesions,also involving the brain stem,cerebellum,thalamus and other parts.Conclusion The clinical characteristics and neuroimaging performances of RPLS has certain characteristics,the majority of lesions were reversible,if the early diagnosis and treatment,the prognosis is usually good.

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