The analysis of the effect of transsphenoidal microsurgical operation in patients with prolatinomas

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Author:
HUANG Zhi-min(Department of Neurosurgery, the People's Hospital of Meishan , Meishan , Sichuan 620010, China)
LONG Hong-chuan(Department of Neurosurgery, the People's Hospital of Meishan , Meishan , Sichuan 620010, China)
LUO An-zhi(Department of Neurosurgery, the People's Hospital of Meishan , Meishan , Sichuan 620010, China)
WU Yun(Department of Neurosurgery, the People's Hospital of Meishan , Meishan , Sichuan 620010, China)
ZHANG Zong-yin(Department of Neurosurgery, the People's Hospital of Meishan , Meishan , Sichuan 620010, China)
YU Hua-lin()
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Issue:
Volume 19, Issue 20, 2012
DOI:
10.3760/cma.j.issn.1008-6706.2012.20.002
Key Word:
Somatotropinoma; Operation ; Effects

Abstract: Objective To assess the recent effect of the invasiveness and transsphenoidal microsurgical operation in the treatment of growth hormone-secreting adenom tumor.Methods The data of 22 patients with growth hormone(GH) adenomas were collected.All patients were tested preoperative GH level and that within the first 3 days,30 days following surgery.The invasiveness of pituitary adenomas was judged according to Hardy's classification scheme modified by Wilson.Results There were 22 patients with GH-secreting pituitary adenomas,8 males and 14 females,11 patients with invasive adenomas and 11 patients with noninvasive adenomas.The remission rate between the patients with invasive adenomas and the patients with non-invasive adenomas had no statistically significant difference (P > 0.05 ).The postoperative remission rate of patients with GH values ≤ 50μg/L was no significantly lower than that of > 50μg/L( P > 0.05).Conclusion The recent effects of operation were not significantly different with the invasiveness of tumor.

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