Abstract： Objective To compare the biomechanical differences between injectable calcium sulfate hemihydrate to fill the bone graft fixed and a simple fixed tibial plateau fractures.Methods Create a rabbit osteoporosis tibial plateau collapse fracture model,filled with calcium sulfate bone graft and Kirschner wire fixation on a regular basis based on general observation,the general X-ray,bone mineral density ( BMD ) analysis,non-decalcified biopsy,mechanical loading experiment.Results Ordinary X-ray observations suggested that the fracture zone filled with calcium sulfate gradually degraded and absorbed by new bone tissue replacement.The 1,2,3,4,6,8,12 weeks after the filling of the bone cement treatment group rabbit calcium sulfate bone cement sample of the BMD of the fracture,the axial load carrying capacity was significantly higher than the blank control group,the difference was statistically significant ( P ＜ 0.01 ).Conclusion Osteoporosis rabbit tibial plateau fracture filling calcium sulfate bone cement early can increase bone density,improve the axial load carrying capacity.