The influence of edaravone on cognitive ability in patients with vascular dementia
- Author:
- No author available
- Journal Title:
- Chinese Journal of Primary Medicine and Pharmacy
- Issue:
- 18
- DOI:
- 10.3760/cma.j.issn.1008-6706.2012.18.005
- Key Word:
- 痴呆,血管性;认知障碍;依达拉奉注射液;吡拉西坦;Dementia,vascular;Cognition disorders;Edaravone injection;Piracetam
Abstract： Objective To observe the influence of edaravone on the cognitive ability in patients with vascular dementia(VD).Methods 70 cases with mild to moderate VD were randomly divided into observation group( edaravone treatment) and control group( piracetarn treatment),35 cases in each group.Treatment cycle was two weeks.The scores of MMSE,CDT,MoCA were compared before and after treatment between the two groups.Results The scores were found to be significantly higher after use edaravone in the observation group ( t =4.21,1.45,12.37,all P ＜0.05 ).The score had no difference before and after treatment in the control group ( P ＞ 0.05 ).Conclusion Edaravone could improve cognitive abilitys in VD patients through its function of anti-oxidant and free-radical scavenging.
- [1]但德胜,薛敬明,程礼丽,等.依达拉奉治疗急性脑卒中的疗效观察[J].2011,(2).
- [2]谭江南.依达拉奉治疗急性脑梗死96例疗效观察[J].2011,(14).
- [3]王蔚,丁新生,肖杭,等.依达拉奉对原代海马神经元缺氧复氧损伤的保护作用[J].2007,(4).
- [4]金炜,陈观保,徐文锐.依达拉奉治疗急性脑梗死42例疗效分析[J].2010,(5).
- [5]衣永尚,韩旭东,王帅,等.奥拉西坦胶囊联合尼莫地平治疗血管性痴呆的疗效及安全性评价[J].2012,(2).
- [6]张峰,郭洪志.依达拉奉治疗血管性痴呆临床观察[J].2010,(3).
- [7]吴义方,林群力,余晗,等.神经节苷酯注射液治疗血管性痴呆的疗效观察[J].2011,(10).
- [8]全凤英,谭家泽,王咏龙.依达拉奉对血管性痴呆大鼠认知功能损害的保护作用[J].2010,(21).
- [9]陈永军.针灸治疗血管性痴呆的疗效分析[J].2011,(20).
- [10]李高义,陈劲草,孟肖利,等.依达拉奉对大鼠脑缺血再灌注损伤后神经保护作用的研究[J].2008,(1).
- [11]吴义方.加用依达拉奉治疗血管性痴呆的疗效观察[J].2006,(3).
- [12]林森,赵颖,王建华,等.依达拉奉对血管性痴呆大鼠脑组织β淀粉样蛋白、Tau蛋白表达的影响[J].2011,(29).
- [13]蔡建伟,吴颢昕,晋光荣,等.双根清脑煎剂对血管性痴呆大鼠模型脑海马组织及血清SOD MDA的影响[J].2007,(6).
- [14]Yabe T,Takanashi M,Tokunaga K,etc.Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection.[J].2006,119(4).