Expression and clinical significance of BRMS1 protein in colon cancer
- Author:
- No author available
- Journal Title:
- Chinese Journal of Primary Medicine and Pharmacy
- Issue:
- 13
- DOI:
- 10.3760/cma.j.issn.1008-6706.2012.13.003
- Key Word:
- 结肠肿瘤;基因,肿瘤抑制;免疫组织化学;Colon neoplasms;Genes,tumor suppressor;Immunohistochemistry
Abstract： Objective To investigate the expression and clinical significance of BRMS1 ( breast cancer metastasis suppressorl ) protein in colon cancer.Methods The expression of BRMS1 protein was detected by using EliVision immunohistochemical techniques in 46 cases of colon cancer,and adjacent non cancerous colon tissues.The clinical significance with histopathologic records was aralyzed.Results The expression levels of BRMS1 ( 34.8％ ) in the colon cancer tissues was significantly lower than those of adjacent non cancerous colon tissues( x2 =23.92,P ＜0.01 ).The expression of BRMSl was significantly correlated with tumor size,clinical stage,and lymph node status (x2 =6.02,4.28,4.35,all P＜0.01) ;BRMS1 had no correlation with age,pathological type.Conclusion BRMS1 might synergistically promote the metastasis of colon cancer.Detection of the expression of BRMS1 may be hdpful in determineing the prognosis of colon cancer.
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