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Influence of Danshen injection on the serum levels of TNF-α, IL-6 in patients with acute pancreatitis

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Author:
No author available
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Issue:
10
DOI:
10.3760/cma.j.issn.1008-6706.2012.10.005
Key Word:
胰腺炎;丹参注射液;肿瘤坏死因子α;白细胞介素6;Pancreatitis;Danshen injection;Tumor necrosis factor α;Interleukin 6

Abstract: Objective To observe the influence of Danshen injection on the serum levels of TNF-α,IL-6 in patients with acute pancreatitis(AP).Methods 70 patients with AP were randomly divided into the experimental and control group.The two groups were given conventional anti-inflammatory,antisecretory,antispasmodic,inhibition of pancreatic secretion treatment,and the experimental group were treated with Danshen injection.Before trealment and 1,2,4,6 days after treatment,the serum TNF-α,IL-6 levels were measured in both groups.The time of blood and urine amylase(AMS) returned to normal was observed in both groups.Results 2,4,6d after treatment,the serum TNF-α,IL-6 of the observation group were lower than that of the control group( all P < 0.05 ) ;The blood AMS recovery time of the observation group was ( 2.55 ± 0.71 ) d,which had no significant difference with that of the control group(2.46 +0.82)d(t =0.32,P >0.05 ),while urinary AMS recovery time of the observation group was (4.30 ±0.72 ) d,which was shorter than that of the control group ( 6.84 ± 0.88 ) d ( t =0.02,P < 0.05 ).Conclusion Danshen injection could reduce the serum TNF-α,IL-6 levels in patients with AP,and had no effect on the serum amylase,with the trend of faster lower urinary amylase.

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