Influence of Danshen injection on the serum levels of TNF-α, IL-6 in patients with acute pancreatitis

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Author:
SHI Xiu-quan(Department of The Second Surgery,the People's Hospital of Yingshang County,Anhui 236200, China)
GUO Peng(Department of The Second Surgery,the People's Hospital of Yingshang County,Anhui 236200, China)
LI Wen-xuan(Department of The Second Surgery,the People's Hospital of Yingshang County,Anhui 236200, China)
QIANG Ze-hao(Department of The Second Surgery,the People's Hospital of Yingshang County,Anhui 236200, China)
SHEN Da-you(Department of The Second Surgery,the People's Hospital of Yingshang County,Anhui 236200, China)
L(U) Nai-chang(Department of The Second Surgery,the People's Hospital of Yingshang County,Anhui 236200, China)
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Issue:
Volume 19, Issue 10, 2012
DOI:
10.3760/cma.j.issn.1008-6706.2012.10.005
Key Word:
Pancreatitis;Danshen injection;Tumor necrosis factor α;Interleukin 6

Abstract: Objective To observe the influence of Danshen injection on the serum levels of TNF-α,IL-6 in patients with acute pancreatitis(AP).Methods 70 patients with AP were randomly divided into the experimental and control group.The two groups were given conventional anti-inflammatory,antisecretory,antispasmodic,inhibition of pancreatic secretion treatment,and the experimental group were treated with Danshen injection.Before trealment and 1,2,4,6 days after treatment,the serum TNF-α,IL-6 levels were measured in both groups.The time of blood and urine amylase(AMS) returned to normal was observed in both groups.Results 2,4,6d after treatment,the serum TNF-α,IL-6 of the observation group were lower than that of the control group( all P < 0.05 ) ;The blood AMS recovery time of the observation group was ( 2.55 ± 0.71 ) d,which had no significant difference with that of the control group(2.46 +0.82)d(t =0.32,P >0.05 ),while urinary AMS recovery time of the observation group was (4.30 ±0.72 ) d,which was shorter than that of the control group ( 6.84 ± 0.88 ) d ( t =0.02,P < 0.05 ).Conclusion Danshen injection could reduce the serum TNF-α,IL-6 levels in patients with AP,and had no effect on the serum amylase,with the trend of faster lower urinary amylase.

  • [1]贾鹏辉,张肇达.急性胰腺炎早期胰腺微循环的改变.中国普外基础与临床杂志,2005,11(12):92-94.
  • [2]Gerasimenko JV,Lur G,Sherwood MW,et al.Pancreatic protease activation by clcohol metabolite depends on Ca2 + release via acid store IP3 receptors.Proc Natl Acad Sci USA,2009,106 (26):10758-10763.
  • [3]李军成,田斌,陈易人,等.急性胰腺炎急性期胰腺病理与血清细胞因子的关系.肝胆外科杂志,2003,6(11):457-460.
  • [4]徐华峰,王建胜丹参注射液对急性胰腺炎患者细胞因子和血栓素A2/列环素平衡的影响.中国基层医药,2010,17(9):1266-1267.
  • [5]吴林飞,陈小燕,闫峻.急性胆源性胰腺炎大鼠血清白细胞介素-8的变化.中国基层医药,2010,17(24):3397-3399.
  • [6]鲍兵.急性胰腺炎外周血TNF-α、IL-6、slL-2R对评价疾病严重程度的意义.山西医药杂志,2006,35(3):253-254.
  • [7]王凯,王昊.丹参注射液临床应用进展.河南医药信息,2002,12(6):66-67.
  • [8]时立新.丹参的临床药理研究新进展.武警医学,2005,16(10):779-780.
  • [9]中华医学会消化病学分会胰腺疾病学组.中国急性胰腺炎诊治指南(草案).胰腺病学,2004,4(1):35-38.
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