Abstract: Objective To compare the effect and side effects of citalopram and fluoxetine in the treatment of depression.Methods 46 cases meet the diagnostic criteria of CCMD-3 in patients with depression were randomly divided into citalopram group and fluoxetine group,treatment for 6 weeks,with Hamilton Depression Rating Scale (HAMD) and Emergent Symptom Scale(TESS) assessed the efficacy and adverse reactions.Results The efficiercy in citalopram group was 75.4%,74.8% for the fluoxetine group,the difference between the two groups was not significant ( P>0.05).Affter 2weeks treatment HAMD score between the two groups was significantly different (P < 0.05),TESS score in Citalopram group was lower than the fluoxetine group,the differences were significant ( P < 0.05 ).Conclusion Citalopram and fluoxetine have good antidepressant effects.Citalopram has the advanteges of early onset,cess adverse reactions.