Study on the relationship between eradication of helicobacter pylori infection and CYP2C19 genetic mutation
- Author:
- No author available
- Journal Title:
- Chinese Journal of Primary Medicine and Pharmacy
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-6706.2012.07.002
- Key Word:
- 螺杆菌,幽门;细胞色素P450酶系统;埃索美拉唑;变异(遗传学);Helicobacter pylori;Cytochrome P-450 enzyme system;Esomeprazole;Variation (Genetics)
Abstract： Objective To investigate the effect of different CYP2C19 genotype on the eradication rate of helicobacter pylori(Hp).Methods 60 cases with Hp eradication failure underwent the CYP2C19 gene detection,in which the gene EM in 49 cases of test group,PM in 11 cases as control group,were given esomeprazole triple therapy,after the end of treatment 14C negative rate was anahyzed.Results 49 cases of test group after treatment,the Hp eradication rate was 79.6％,compared to the control group for the Hp eradication rate was 100.0％,the control group was better than the experimental group with significant difference(X2 =9.475,P ＜ 0.05 ).Conclusion Hp eradication failure in CYP2C19 patients with strong metabolic type (49/60) for much,given again esomeprazole treatment could improve the strong metabotropic efficacy,and espectially for the weak metabolic genotype effect.
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