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The expression and clinical significance of MMP-2 、MMP-9 and VEGF in tongue squamous cell carcinoma

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Author:
No author available
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Issue:
3
DOI:
10.3760/cma.j.issn.1008-6706.2012.03.021
Key Word:
舌;癌,鳞状细胞;血管内皮生长因子;基质金属蛋白酶-2;基质金属蛋白酶-9;Tongue;Carcinoma,squamous cell;vascular endothelial growth factor;matrix metallop roteinase-2;matrix metalloproteinase-9

Abstract: Objective To investigate the expression of vascular endothelial growth factor (VEGF)、matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9 (MMP-9) in tongue squamous cell carcinoma and the clinical significance.Methods The expression of MMP-2,MMP-9 and VEGF in 60 cases of tongues quamous cell carcinoma tissues and in 20 cases of normal tongues tissues were examined by immunochemistry.Results The expression of MMP-2,MMP-9 and VEGF was higher in tongues quamous cell carcinoma than that in normal pancreatic parenchyma.In cases with lymph nodes metastasis and TNM stage Ⅲ + Ⅳ,the expression of two markers were significantly higher than those without lymph nodes metastasis and TNM stage Ⅰ + Ⅱ (P < 0.05).A positive correlation was found between the expression of VEGF and MMP-2,MMP-9 in tongues quamous cell carcinoma ( P < 0.05 ).Conclusion The expression of MMP-2,MMP-9 and VEGF was closely correlated with lymph nodes metastasis and TNM stage of tongues quamous cell carcinoma(P < 0.05 ).VEGF and MMP-2,MMP-9 play an important role in the development of tongues quamous cell carcinoma,may cooperate with each other.

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