Risk analysis of upper gastrointestinal bleeding in elderly patients with aspirin and clopidogrel co-therapy
- Author:
- No author available
- Journal Title:
- Chinese Journal of Primary Medicine and Pharmacy
- Issue:
- z2
- DOI:
- 10.3760/cma.j.issn.1008-6706.2011.s2.003
- Key Word:
- 胃肠出血;阿司匹林;氯吡格雷;老年人;Gastrointestinal hemorrhage;Aspirin;Clopidogrel;Aged
Abstract： Objective To explore the current occurrence of upper gastrointestinal bleeding in elderly patients in our hospital and its possible risk factors and treatment program.Methods An observational prospective analysis of medical records of 758 consecutive patients was performed.Clinical presentation,etiology and treatment were evaluated.The follow-up ended on the dates of a first occurrence of UGIB,stopping co-therapy,death or 6 months after admitted in the group.Results 426 male and 332 female were admitted in the group,UGIB occurred in 48 patients.PPI,H2RA,gastric mucosa protectant plus PPI,gastric mucosa protectant plus H2RA and control were prescribed in 108,240,70,102,238 patients respectively.There were statistics difference in each group compared with control in bleeding rate.Conclusion The occurrence of UGIB associated with A + C co-therapy in elderly was 6.3％.Co-prescription with PPI and gastric mucosa protectant was associated with a lower risk.
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