Study on the correlation between plasma aminopeptidase A and essential hypertension
- Author:
- No author available
- Journal Title:
- Chinese Journal of Primary Medicine and Pharmacy
- Issue:
- 24
- DOI:
- 10.3760/cma.j.issn.1008-6706.2011.24.002
- Key Word:
- 高血压,原发性;肾素-血管紧张素系统;血管紧张素Ⅱ;氨基肽酶A;Essential hypertension;Renin-angiotensin system;Angiotensin Ⅱ;Aminopeptidase A
Abstract： Objective To study the correlation between essential hypertension and plasma aminopeptidase A.Methods The people of the Han nationality in Huainan city received questionnaire investigation and their blood pressure,height and weight were measured.131 individuals suffered from hypertension and 134 healthy individuals belongs to hypertensive pedigree and 127 individuals suffered from hypertension and 132 healthy individuals belongs to non-hypertensive pedigree were reseached.The level of Ang Ⅱ in plasma was detected by RIA,and the level of APA was detected by ELISA.Results The levels of Ang Ⅱ and APA in plasma in HP group was significantly higher than that in NHP group in two pedigrees ( t =10.3398,6.5613,11.7089,6.6683,all P ＜ 0.01 ).Furthermore,the levels of Ang Ⅱ and APA in plasma in HP group in hypertensive pedigree was significantly higher than that in HP group in nonhypertensive pedigree(t =3.6201,6.1091,all P ＜ 0.01 ).There was significantly positive correlation between MAP and the levels of Ang Ⅱ and APA in plasma in HP group in two pedigrees ( r =0.315,0.392,all P ＜ 0.05 in non-hypertensive pedigree,and r =0.412,0.505,all P ＜ 0.01 in hypertensive pedigree ).There was positive correlation between the levels of Ang Ⅱ and APA in plasma in HP group in hypertensive pedigree ( r =0.322,P ＜ 0.05 ).Conclusion There was significant difference between hypertensive pedigree and non-hypertensive pedigree in the levels of APA;The levels of APA in plasma in HP group was significantly increased in the individuals suffered from hypertension,and was positively correlated with MAP.
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