Abstract： Objective To evaluate the efficacy and toxicity of Gemcitabine combined with Cisplatin in the treatment of advanced non-small cell lung cancer.Methods Gemcitabine 1000 ～ 1250mg/m2,intravenous infusion,on d 1,8,Cisplatin 80mg/m2,intravenous infusion,on d1 or d1 ～ 3,the regimen was repeated every 21 days,completed at least 2 cycles.Results Thirty-seven patients were evaluated.None achieved CR,16 patients achieved PR,13 patients achieved SD,the overall response rate( CR + PR) was 43.2％,and the disease control rate( CR + PR + SD) was 78.4％.The most common toxicities were bone marrow suppression,nausea and vomiting.Conclusion The regimen of Gemcitabine combined with Cisplatin in the treatment of advanced non-small cell lung cancer was safe and effective,and the toxicity could be tolerated.