Abstract: Objective To analyze hospital isolated from 371 acinetobacter baumannii the distribution of the infection characteristics and drug resistance.Methods Of the first people's hospital of Kaifeng the samples of isolated 371 acinetobacter baumannii was selected,according to the " national clinical laboratory operating procedures,"the third edition of the conventional culture isolation,identification of bacteria using the French company bioMérieux VITEK-32 microbial automatic analyzer and GNI + cards for identification.France bioMérieux VITEK2 using automated microbial analysis system and supporting the identification and drug Minka for bacterial identification and susceptibility testing ( MIC method),drug susceptibility results in the standard to judge by CLSI2006.Using the World Health Organization drug monitoring network provided WHONET 5.0 software for data analysis.Results 315 sputum detected,accounting for 84.9% ; pleural effusion 32,8.6% ;pus 21,5.7% ;urine 3,0.8%.Respiratory Medicine,124,33.4% ;Geriatrics 81,21.8%.Of acinetobacter baumannii resistance to minocycline was the lowest (3%),the highest resistance to azithromycin( 100% ).Conclusion The pan-resistant Acinetobacter baumannii,minocycline as a drug of choice,imipenem could be used as first-line drugs.