Abstract： Objective To discuss the mental state and its influencing factors of perioperative patients with mania.Methods 40 perioperative mania patients were investigated with Bech-Rafaelsdn Mania Rating Scale (BRMS) and Life Event Scale(LES) ,assisted with self-designed influential factors to survey the correlation factors.Results The perioperative patients were interestd in therapeutic correlation question preoperative and worry about their recovery after operation.The worry showed that operations was mental work load and psycho-burden to the patients.Perioperative patients' mental activities were main of perceptual insecurity.The psycho-feature must influence the compliance of mania patients' therapy and nursing.What follows next is the quality of therapy and nursing.Conclusion The main problem to be solved is intervention the tension, anxiety, scare psychology of the patients in perioperative.At the same time it must be strengthened to talk to the family member of the patients knowledge about the disease and its recovery.