Comparison of the effect of fenofibrate and atorrastubin in treating hyperlipoidemia and hyperuricemia

( views:128, downloads:0 )
Author:
LI Fang(Department of Neurology, The First Affiliated Haerbin Medical University, Haerbin,Heilongjiang 150001, China)
SUN Rui-hong(Department of Neurology, The First Affiliated Haerbin Medical University, Haerbin,Heilongjiang 150001, China)
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Issue:
Volume 18, Issue 17, 2011
DOI:
10.3760/cma.j.issn.1008-6706.2011.17.004
Key Word:
Hyperlipoidemia;Hyperuricemia;Fenofibrate;Atorvastatin

Abstract: Objective To explore the effect of fenofibrate and atorvastatin on hyperlipoidemia and hyperuricemia.Methods 55 cases were randomly divided into 2 groups. 30 cases in the treatment group were give Fenofibrate (200rmg/d) and 25 cases in control group were given atorvastatin(10mg/d). And two groups given 8 days for all patients. The therapeutic effect, blood-fat and blood uric acid levd, and complication in two groups were compared. Results There were conspicuous effect of fenofibrate and atorvastatin on hyperlipoidemia and hyperuricemia. The index of TG, TC had significant differences between the two groups. The index of acidum uricum was higher in control group.The complication had no significant differences between two groups. Conclusion Both fenofibrate and atorvastain were effective drug for hyperuricemia and hyperlipoidemia,and could reduce TC,TG, HDLC and LDLC in the short time,and could decrease the risk factor of cerebrovascular disease.

  • [1]Feig DI,Kang DH,Johnson RJ.Uric acid and cardiovascular risk.N Engl J Med,2008,359(17):1811-1821.
  • [2]中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南.中华心血管病杂志,2007,35(5):390-419.
  • [3]向月应,眭维国,邹贵勉.高尿酸血症肾损害社区流行病学调查及其危险因素分析.中华保健医学杂志,2009,11(3):195-197.
  • [4]胡政国,刘家铎.苯溴马隆与别嘌醇治疗高尿酸血症的疗效比较.中国基层医药,2010,17(18):2506-2507.
  • [5]刘英.高尿酸血症与高血压、高血脂、高血糖关系分析.首都医药,2009,16(14):25-26.
  • [6]谷现恩,闫治安.高尿酸血症和痛风的诊疗策略.中国临床医生,2009,37(1):13-14.
  • [7]傅得兴.别嘌醇的不良反应及安全应用.药物不良反应杂志,2003,5(3):173-176.
  • [8]贺范龙,钱瑾瑜.辛伐他汀联合菲诺贝特治疗混合性高脂血症62例临床观察.中国基层医药,2009,16(6):1113-1114.
  • [9]王倩,包存刚.不同剂型非诺贝特对大鼠血脂水平的影响.中国药理学通报,2003,19(7):833-836.
  • [10]任力群,黄敏秀.微粒化非诺贝特与阿托伐他汀对不同类型高脂血症患者血脂水平的影响.医学导报,2006,25(7):664-666.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn