Abstract： Objective To explore the effect of fenofibrate and atorvastatin on hyperlipoidemia and hyperuricemia.Methods 55 cases were randomly divided into 2 groups. 30 cases in the treatment group were give Fenofibrate (200rmg/d) and 25 cases in control group were given atorvastatin(10mg/d). And two groups given 8 days for all patients. The therapeutic effect, blood-fat and blood uric acid levd, and complication in two groups were compared. Results There were conspicuous effect of fenofibrate and atorvastatin on hyperlipoidemia and hyperuricemia. The index of TG, TC had significant differences between the two groups. The index of acidum uricum was higher in control group.The complication had no significant differences between two groups. Conclusion Both fenofibrate and atorvastain were effective drug for hyperuricemia and hyperlipoidemia,and could reduce TC,TG, HDLC and LDLC in the short time,and could decrease the risk factor of cerebrovascular disease.