Clinical study on deanxit in the treatment of post-stroke depression

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Author:
SUN Ai-guo(Department of Neurology, The First Hospital Affiliated to Haerbin Medical University ,Haerbin,Heilongjiang 150001, China)
SUN Rui-hong(Department of Neurology, The First Hospital Affiliated to Haerbin Medical University ,Haerbin,Heilongjiang 150001, China)
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Issue:
Volume 18, Issue 17, 2011
DOI:
10.3760/cma.j.issn.1008-6706.2011.17.002
Key Word:
Flupentixol/melitracen;Depression;Cerebrovascular accident

Abstract: Objective To evaluate the efficacy of deanxit in treatment of post-stroke depression (PSD).Methods60 patients with PSD were randomly divided into treatment group ( plus with deanxit) and control group (plus with estazolam necessarily). At the baseline and at 2 weeks,4 weeks, 8 weeks after the treatment, the efficacy was assessed with HAMD, SSS, and ADL rating scale respectively. Results After 2,4,8 weeks treatment, HAMD and SSS scores of the treatment group significantly decreased compared with the control group ( all P < 0. 01 ), and ADL scores of the treatment group increased significantly compared with the control group ( P < 0. 01 ). Conclusion Deanxit could effectively relieve depressing symptoms and neurological impairment of PSD, and clinical side effects of deanxit were less. Deanxit was suitable for acute phase and long-term maintenance therapy in PSD.

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