Abstract: Objective To evaluate the effect and complication of whole γ-knife stereotactic radiotherapy on the non-small cell lung cancer and explore the value of γ-knife stereotactic radiotherapy in treatment of non - small cell lung cancer. Methods 42 patients with non -small cell lung cancer:γ-knife radiotherapy patients ,4 ~ 8Gy once a day,five times a week,4 ~ 10times and 40 ~50Gy in total. Results The overall response rate (CR + PR) in γ-knife was 71.4%. The1-,2-and 3-year survival rates were 95.5%, 59.5%, 33.3%. Conclusion Compared with conventional radiation,γ-knife stereotactic radiotherapy could achieve tumor dose escalation,and give the normal tissue better protection at the same time. It could improve the tumor control rate of non-small cell lung cancer,improve long survival rate,and so could reduce the radiation reaction.