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Cilnical significance of serum human kallikrein 11 in patients with ovarian cancer

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Author:
No author available
Journal Title:
Chinese Journal of Primary Medicine and Pharmacy
Issue:
15
DOI:
10.3760/cma.j.issn.1008-6706.2011.15.002
Key Word:
卵巢肿瘤;组织激肽释放酶类;Ovarian neoplasms;Tissue kallikrein

Abstract: Objective To investigate the diagnostic and prognostic significance of serum human kallikrein11 ( KLK11 ) in patients with ovarian cancer. Methods The level of serum KLK11 was determined by enzyme-linked immunoassay(ELISA) for 30 patients with ovarian cancer, 26 patients with benign gynecologic processes and 32 healthy subjects,and the KLK11 value beyond the upper-limit of 95% credibility interval( 95% CI) based on the health controls was used as the positive value. The positive rate of KLK11 was compared among the three groups.Results The positive rate of KLK11 in patients with ovarian cancer was significantly higher than those in patients with benign gynecologic processes or in healthy subjects[(73.3%) and(7.7% ) or(6.3% ) ,all P <0.01 )] ,and there was no significant difference between ovarian benign tumor group and the healthy control group ( P > 0.05 ).Conclusion The serum KLK11 should be a novel tumor marker in the clinical diagnosis of ovarian cancer.

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