Abstract： Objective To observe the effect of tripterygium wilfordii combined with low molecular hepatin in treatment of chronic nephritis.Methods 102 patients who underwent renal biopsy and diagnosed as chronic nephritis were randomly divided into treatment group and control group,each contained 51 patients.The control group were given ordinary western medicine,and both continued for therapeutical period of 4 weeks.the treatmem group were given tripterygium wilfordii and low molecular heparin besides ordinary western medicine.Results The treatment group's total effective rate 90.20%was obviously higber than the control group's 74.51%.and compared with the control group,there was significandy statistical difference(P＜0.05).After 4 weeks treatment,the treatment group's urine protein and serum creatinine、urea nitrogen compared with the control group also had significant differences all P＜0.05).Conclusion Tripterygium wilfordii combined with low molecular heparin could difinltely reduce the chronic nephritis patients' urine protein and serum creatinine、urea nitrogen,and had less side effect,and it Was worthy of being widely used.