Dose of expression and study of the theory for adverse reactions of cefamandole nafate for injection- Gold Zone Method

( views:226, downloads:0 )
Author:
LIU Jian-ping(Beijing children's hospital affiliated to Capital Medical University, Beijing 100045, China)
SHI Xue(Beijing children's hospital affiliated to Capital Medical University, Beijing 100045, China)
Journal Title:
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
Issue:
Volume 18, Issue 05, 2011
DOI:
10.3760/cma.j.issn.1008-6706.2011.05.001
Key Word:
Golden section;Maximum tolerated dose;Drug utilization review;The Doctrine of the Golden mean

Abstract: Objective Inaccurate dosing is an important cause of medical malpractice, how to adjust the medication dose to overcome the excessive deviation will be discussed in this paper. Methods Gold zone method was proposed on the basis of the probability theory and mathematical statistics for handling inaccurate dosing problems. Investigation and study in large sample size was carried out on adverse reactions of Cefamandole Nafate for Injection by adopting the method. Results The conclusions from the super large sample size test indicate that there is highly significant difference of total adverse reaction rates between taking values within and outside golden zone of dosage, and the adverse reaction rate of taking values within golden zone is significantly lower than that of outside golden zone. It is noteworthy that when dosage was lower than golden zone,the adverse reaction rate was significantly increased,which is more than 4 times of that within golden zone. Conclusion It is effective measures and simply and easy to apply that taking values within golden zone of dosage reduce adverse drug reactions,probability within golden zone less than 1/4 range of experience that contains the actual demand of the body up to 70%.

  • [1]刘建萍.黄金区域法应该成为健康和医药的重要理念.现代预防医学,2007,34(12):2266-2267.
  • [2]刘建萍.中药注射剂的发展道路如何走.中国药房,2007,18(27):2081-2083.
  • [3]金菊庆,王锦红.药物不良反应117例报告分析.中国基层医药,2009,16(15):918.
  • [4]量身定制儿童药物-儿童和药物的10个事实.http://www.moh.gov.cn/publicfiles/business/ htmlfiles/mohbgt/s6716/200806/36287.htm.
  • [5]刘春香.儿童门诊用药分析.中国基层医药,2009,16(15):908.
  • [6]戴建业.老子现代版.上海:上海古籍出版社,2002:294.
  • [7]陈戍国.四书校注.长沙:岳麓书社,2004:42.
  • [8]张登本,孙理军,译.全注全译黄帝内经.北京:新世界出版社,2008.
  • [9]大不列颠百科全书:5卷.北京:中国大百科全书出版社,2005:221.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn