The expression of tumor necrosis factor-α and its significance in different gestational period placentas and aging placentas
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1008-6706.2011.04.001
- Key Word:
- 胎盘老化;肿瘤坏死因子-α;肿瘤坏死因子受体;Placenta aging;TNF-α;TNF-R
Abstract： Objective To study the differences of tumor necrosis factor-α in different gestational period placentas and aging placentas and to analyze its significances. Methods Using immunohistochemistry to detect the expression and distribution of tumor necrosis factor-α in different gestational period placentas and aging placentas. Results The expression of tumor necrosis factor-α was significantly higher in the third trimester of pregnancy placentas and aging group than in the first trimester of pregnancy placentas(P＜0.05),and than in the second trimester of pregnancy placentas(P＜0.05).The expression of tumor necrosis factor-α had no significant difference between the third trimester of pregnancy placentas and aging group(P＞0.05). Conclusion TNF-α should play an important role in placental aging.
- [1]曲广第,王冬梅.TNF-α、IL-6在妊娠肝内胆汁淤积症胎盘上的表达[J].2004,(3).
- [2]甄学慧,范艳艳,李万斌,等.瘦素、肿瘤坏死因子与妊娠期高血压疾病的相关性研究[J].2007,(28).
- [3]纪文婷,许严伟,张霄翔,等.肿瘤坏死因子相关凋亡诱导配体的原核表达、纯化及抗肿瘤活性研究[J].2008,(4).
- [4]龙凤宜,范江涛,李建华.血清孕酮、IL-8、TNF-α在先兆流产中的意义[J].2006,(2).
- [5]申龙英.血清肿瘤坏死因子和白细胞介素-6与早产的关系研究[J].2010,(6).
- [6]何勇,刘树琴,王长江,等.IL-6、TNF-α在绝经后骨质疏松症发生中的作用[J].2007,(1).
- [7]杨鹃,王豫黔,丛棣,等.细胞因子与胎儿宫内发育受限胎盘凋亡相关性研究[J].2002,(3).
- [8]冯冲,陶永健,尚涛,等.子痫前期患者胎盘组织中RAGE、TNF-α的表达及临床意义[J].2009,(20).
- [9]张智峰,牛光明,宋来君,等.肿瘤坏死因子相关凋亡诱导配体诱导人脑胶质瘤细胞凋亡作用的研究[J].2005,(10).
- [10]郝国荣,沈雪燕.细胞因子与妊娠滋养细胞疾病[J].2009,(4).
- [11]张闻多,马青变,史力斌,等.白介素10对肿瘤坏死因子-α诱导心肌细胞凋亡的影响及其作用机制[J].2010,(11).
- [12]吴化平,刘新菊,范书萍.妊娠高血压综合征患者血清肿瘤坏死因子-α水平及胎盘组织缺氧诱导因子的表达[J].2007,(18).
- [13]M A, Williams,A, Farrand,R, Mittendorf,etc.Maternal second trimester serum tumor necrosis factor-alpha-soluble receptor p55 (sTNFp55) and subsequent risk of preeclampsia.[J].1999,149(4).
- [14]T, Jo,T, Tomiyama,K, Ohashi,etc.Apoptosis of cultured mouse luteal cells induced by tumor necrosis factor-alpha and interferon-gamma.[J].1995,241.
- [15]H L, Chen,Y P, Yang,X L, Hu,etc.Tumor necrosis factor alpha mRNA and protein are present in human placental and uterine cells at early and late stages of gestation.[J].1991,139(2).