Abstract： Objective To explore the clinical application value of transcranial Doppler on patients with hyperlipidemia. Methods 80 patients with hyperlipemia and 70 healthy people were studied by transcranial Doppler ultrasound(TCD) of interal carotid artery hemodynamics. Results 57 (71.7%)of the 80 patients with hyperlipemia had arteriosclerosis, and terminal sclerosis happened on 12 patients ( 13.3% ). Compared with the control group, the difference was all statistically significant ( P ＜ 0.05 ). Conclusion Hemodynamics at the terminal of interal carotid artery patients with hyperlipemia was obvious abnormal studied by transcranial Doppler ultrasound (TCD) , and sclerosis of interal carotid artery is common complication of patients with hyperlipemia. Results showed that TCD could be used as a routine method for testing of patients with hyperlipemia and had some value in preventing cerebrovascular disease induced by hyperlipidemia.