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Expression and clinical significance of CD44v3 and VEGF-C in gastric cancers

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
Issue:
20
DOI:
10.3760/cma.j.issn.1008-6706.2010.20.002
Key Word:
胃肿瘤;细胞黏附分子;抗原,CD44;血管内皮生长因子C;Stomach neoplasms;Cell adhesion molecules;Antigens,CD44;Vascular endothelial growth factor C

Abstract: Objective To investigate the expression of CD44v3 and VEGF-C in human gastric cancers and the clinical significance. Methods The expression of CD44v3 and VEGF-C was detected by immunohistochemistry SP method in 92 gastric cancer tissues. Results Positive immunohistochemical stain for CD44v3 was identified in 27.2% of gastric cancer tissues. There was no correlation found among the expression of CD44v3 with sex, location,depth of invasion, WHO type, Lauren type as well as distant metastasis (all P > 0. 05 ). The expression of CD44v3 was positively correlated with lymph node metastasis and tumor differentiation( all P < 0. 05 ). Positive immunohistochemical stain for VEGF-C was identified in 48.9% of gastric cancer tissues. There was no correlation found among the expression of VEGF-C with sex,location, tumor differentiation, depth of invasion, WHO type, as well as distant metastasis ( all P > 0. 05 ). The expression of VEGF-C was positively correlated with lymph node metastasis and Lauren type ( all P <0. 05). Cox-Regression reflected that only the lymphatic metastasis situation correlated with the life ratio( P =0. 015). Conclusion The expression of CD44v3 and VEGF-C could suggest the progression and metastatic potential value of gastric cancer,but didnt correlate with the life ratio. There was no cooperation between CD44v3 and VEGF-C in promoting gastric cancer metastasis.

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