Abstract： Objective To study the expression of leptin in different of types of syndrome in traditional Chinese medicine of GC,explore the relationship between leptin and the type of syndrome. Methods Syndrome type of 75 patients who diagnosis of GC were differentially classified, and the expression of leptin in different types was determined by immunohistochemistry. And 18 patients with superficial gastritis were selected as control. The expressions of leptin in different syndrome types were analyzed by combining with correlated clinical pathological characteristics. Results The leptin positive expression rate in GC patients was 84.3%, and in superficial gastritis patients was 17.6%,the difference was significant ( P < 0.05 ). The intensity of leptin expression showed no evident correlation with sex,age, the size of tumor and its degree of cell differentiation( all P > 0.05 ). It was positively correlated with the depth of tumor infiltration,the extent of lymph node metastasis and the TNM stage( all P <0.05). Level of leptin in various syndrome types was significantly different, the highest expression showed in tanshiningjie type, the second in ganweibuhe type,and the lowest in piweixuhan type. Conclusions Leptin could be taken as an index for evaluating the infiltration,metastasis and prognosis of GC. The expression diversity could be a basis of different types of syndrome.The higher the intensity of evil excess, the more possibilities of tumor infiltration and metastasis and the worse the prognosis could be.