Clinical value of the plasma 1,3-β-D-glucan detection in the diagnosis of penicilliposis marneffei
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 18
- DOI:
- 10.3760/cma.j.issn.1008-6706.2010.18.001
- Key Word:
- 播散性马尔尼菲青霉菌病;1,3-β-D-葡聚糖;Penicilliposis marneffei;1,3-β-D-glucan
Abstract： Objective To evaluate the clinical value of the quantitative detection of plasma 1,3-β-D-glucan in penicilliposis marneffei. Methods The 1,3-β-D-glucan concentrations were detected by using a G test. Results In 60 New Zealand rabbits infected by Penicillium marneffei,the levels of 1,3-β-D-glucan were positively correlated with infectious severity. The sensitivity, specificity, positive predictive rate and negative predictive rate were 88.3%、100%、 100% and 58.8% respectively,which were significantly higher than those of the control group(P <0.01 ).Conclusion The quantitative method for the detection of 1,3-β-D-glucan in plasma was simple,sensitive and reliable, and could be used as the assisting diagnosis of penicilliposis marneffei at early stage.
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