Effects of Edaravone on the levels of hs-CRP and D-dimer in Patients with Acute Cerebral infarction
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 17
- DOI:
- 10.3760/cma.j.issn.1008-6706.2010.17.006
- Key Word:
- 脑梗塞;超敏C反应蛋白;D-二聚体;cerebral infarction;hs-CRP;D-dimer
Abstract： Objective To investigate the effects of edaravone on the levels of high sensitivity C-reactive protein(hs-CRP) and D-dimer in patients with acute ischemic cerebral infarction. Methods A total of 86 patients with acute ischemic cerebral infarction were randomly divided and assigned into therapy group and control group. The control group was given a routine treatment of acute ischemic stroke. The therapy group was treated with edaravone in addition to the routine treatment. hs-CRP and D-dimer were measured before and after treatment. Barthel index(BI) and Chinese stroke Scale(CSS) of two groups were assessed before treatment and after treatment. Results The levels of hs-CRP and D-dimer were deceased after treatment. After the start of edaravone ,the levels of hs-CRP and D-dimer of therapy group were significantly lower than those of control group(P ＜0.05). The scores of CSS and BI of two groups improved after treatment,and scores of CSS and BI of the therapy group were better than those of the control group(P＜ 0.05). Conclusion Edaravone could decrease the levels of hs-CRP and D-dimer and is beneficial to improve neurofunctional recovery.
- [1]陈祖平.红花注射液与依达拉奉联合治疗急性脑梗死临床观察[J].2009,(12).
- [2]杜福文,林晖,黄丽华,等.依达拉奉对重症急性脑梗塞患者超敏C-反应蛋白的影响及临床意义[J].2008,(6).
- [3]魏国荣,徐天昊,彭瑞云.依达拉奉防治缺血性脑损伤研究的新进展[J].2007,(4).
- [4]宋志秀.依达拉奉联合低分子肝素治疗脑梗死疗效观察[J].2008,(8).
- [5]钟立光,张广基,冯清洲.急性脑梗死患者血清高敏C-反应蛋白和D-二聚体水平变化及临床意义[J].2007,(8).
- [6]刘扣琴.依达拉奉治疗急性脑梗死40例近期疗效观察[J].2009,(6).
- [7]高亮.C反应蛋白在急性脑梗死发病中作用机制的探讨[J].2004,(6).
- [8]王新水.脑梗死患者血浆D-二聚体、hsCRP检测及临床意义[J].2007,(13).
- [9]薛文翠,李抒,孙晨,等.急性脑梗死患者血小板活化指标与神经功能缺损评分间的关系[J].2006,(3).
- [10]杨光,赵连东,周永,等.奥扎格雷对急性脑梗死患者血小板CD62p和CD63表达的影响及其疗效[J].2006,(5).
- [11]朱树花,王翠兰.超敏C-反应蛋白在老年急性脑梗死患者中的表达[J].2007,(16).
- [12]陈登青,徐恩.高尿酸血症与脑血管病[J].2005,(2).
- [13]林粤,王北宁,韩玲霞.检测D-二聚体的临床意义[J].2006,(8).
- [14]Ikenoue T,Noor JI,Ikeda T,etc.Edaravone inhibits lipid peroxidation in neonatal hypoxic-ischemic rats: an in vivo microdialysis study.[J].2007,414(1).
- [15]Kang DW,Koh JY,Kim JS,etc.Inflammatory and hemostatic biomarkers associated with early recurrent ischemic lesions in acute ischemic stroke.[J].2009,40(5).
- [16]Maciej, Banach,Leszek, Markuszewski,Janusz, Zas?onka,etc.[The role of inflammation in the pathogenesis of atherosclerosis].[J].2004,58(4).