Application of recombinant human growth hormone combined with early enteral nutrition in severely burned patients
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
- Issue:
- 17
- DOI:
- 10.3760/cma.j.issn.1008-6706.2010.17.004
- Key Word:
- 烧伤;早期肠内营养;生长激素;烧伤脓毒症;Burn;Early enteral nutrition;Recombinant human growth hormone;Burn sepsis
Abstract： Objective To summarize the therapeutic effect of recombinant human growth hormone and early enteral nutrition in severely burned patients. Methods 35 cases were randomly divided into group EN and group PN.Group EN was treated with early enteral nutrition(EEN) and recombiant human growth hormone(rhGH) ,while group PN was given parenteral nutrition. The plasma levels of pre-albumin (PA), C-reactive protein (CRP) , tunmor necrosis factor α(TNFα) ,fasting blood glucose(FBG) were measured after burn injury. Comparision was made in length of hospital stay, wound healing time,incidence of burn sepsis, gastrointestinal stress ulcer bleeding and enteral nutrition intoleranc. Results Incidence of burn sepsis,gastrointestinal stress ulcer bleeding and enteral nutrition intoleranc in group EN were significantly lower than those of group PN(P ＜ 0.05). The serum levels of CRP、TNFα、FBG in group EN were significantly lower than those of group PN (P ＜ 0.05). The serum PA was decreased at all times in two periods and was markedly decreased in group EN(P ＜0.05). Length of hospital stay and the healing time of donor site, deep partial thickness burn wound, skin transplantion area were significantly shortened in group EN compared with group PN. Conclusion Early enteral nutrition was beneficial for the improving of nutrition state of the burn patients,and the reduction of the incidence of burn sepsis and the hospitalization time.
- [1]陈忠勇,谷才之,王少龙,等.烧伤患者早期肠道营养与肠外营养对比观察[J].2004,(4).
- [2]钱天鸿.营养支持对机械通气患者的预后影响[J].2009,(6).
- [3]王玉舟,李文贤,刘柳,等.重度烧伤患者46例并发脓毒症的临床分析[J].2009,(7).
- [4]CHEN Zhong-yong,WANG Shi-liang,Yu Bin,etc.Effects of nutritional support route on intestinal structure and function in the early stage of severe burn injury[J].2001,(2).
- [5]程昌盛,涂燕云.重组人生长激素对终末期肝病患者血清细胞因子水平的影响[J].2010,(2).
- [6]石文,辛乃军,马印东,等.重组人生长激素对烧伤大鼠肠粘膜细胞凋亡的作用[J].2009,(5).
- [7]陈国贤,韩春茂.重组人生长激素影响重度烧伤患者预后的前瞻性多中心研究[J].2005,(5).
- [8]贾军,宋国栋,马印东,等.严重烧伤患者早期应用重组人生长激素的临床效果及安全性分析[J].2008,(2).
- [9]黄春旭,李瑞华,肖敬东,等.食管癌术后吻合口瘘的治疗[J].2009,(6).
- [10]王玉舟,李文贤,郎金田,等.重度和特重度烧伤并发多器官功能障碍综合征的临床特点及防治[J].2009,(13).
- [11]应利君,张燕.胃黏膜pH值检测对评价危重患者早期肠内营养耐受性的价值[J].2010,(8).
- [12]季明霞.生长激素在慢性阻塞性肺疾病急性加重期患者治疗中的应用价值[J].2010,(3).
- [13]陈琍,相胜霞.生长激素结合蛋白与特发性矮小[J].2009,(5).
- [14]邓诗琳,曹丽萍.重组人生长激素在烧伤营养支持中的作用及前景[J].2001,(4).
- [15]吴抽浪,郭光华,李国辉,等.肠内营养联合生长激素对烫伤大鼠肠道的保护作用[J].2006,(3).
- [16]郝岱峰,柴家科,申传安,等.胰岛素强化治疗与重组人生长激素在危重烧伤救治中的联合应用[J].2007,(12).
- [17]汤秀珍,陈键腾,姚慧文.重组生长激素在慢性阻塞性肺疾病机械通气患者中的应用[J].2010,(4).
- [18]Sayeed MM,Choudhry MA,Clark C,etc.Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function.[J].2005,31(3).
- [19]主编吕永慧, 舒建昌, 宋卫兵.肠黏膜屏障与肠内营养[M].1900.
- [20]Marc G, Jeschke,Ullrich, Bolder,Dai H, Chung,etc.Gut mucosal homeostasis and cellular mediators after severe thermal trauma and the effect of insulin-like growth factor-I in combination with insulin-like growth factor binding protein-3.[J].2007,148(1).