Abstract： Objective To explore the abdominal pain as initial symptom of non-digestive diseases,the causes of misdiagnosis. Methods 74 patients with clear diagnosis non-digestive diseases which initial symptom was acute abdominal pain were analyzed. Results The most common causes of misdiagnosis were blood system diseases,circulatory diseases,metabolic diseases,endocrine system diseases,respiratory diseases,nervous system disease,accounting for 35.1% ,25.7% ,10. 8% ,8. 1% ,6. 8% ,6. 8%.The rest,such as the urinary system diseases,toxic diseases were not rare. Conclusion Non-digestive diseases which initial symptom was acute abdominal pain could be caused by the body's various systems,and the causes were complex,the diseases conditions were critical and changed rapidly,so it was difficult to diagnose and had to be Paid attention on.