Abstract： Objective To observe the clinical efficacy on primary biliary cirrhosis(PBC) treated by two methods. Methods 50 cases with PBC were divided into the combination therapy group(A group:n =25) and simple western medicine treatment group(B group:n = 25) ;The curative effect and indicators of liver function were observed before and after treatment in patients with PBC. Results A total effective in group A 19 cases(76.0%) were higher than in B group 15 cases (60.0%) (x~2 = 3.87, P ＜ 0.05) ;The clinical symptoms and signs in A、B group after treatment were better than before treatment(x~2 = 3. 87 ～ 6. 89,P ＜ 0.05 ～ 0.01) ;The clinical symptoms and signs in A group after treatment were better than B group(x~2 = 3.88 ～ 4. 12. ,all P ＜0.05) ;The indicators of biochemical in A、B group after treatment were lower than before treatment(t = 2. 214 ～ 2. 517, P ＜ 0.05); The indicators of biochemical of ALP、GGT、ALT in A group decreased significantly compared with B group(t = 2. 284 ～ 2. 418, P ＜0.05). Conclusion Integrative Chinese and western medicine achieves good clinical efficacy in patients with PBC.