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Effects of erythropoietin on myocardial ischemia-reperfusion injury in rats

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
Issue:
7
DOI:
10.3760/cma.j.issn.1008-6706.2010.07.003
Key Word:
促红细胞生成素;缺血-再灌注损伤;大鼠;Etythropoietin;Ischemia-reperfusion;Bats

Abstract: Objective To study the effects oferythropoietin(EPO)on myocardial ischemia-reperfusion inju-ry(MIPd)in rats.Methods The left anterior descending coronary artery was ligated for 30 minutes and then loosed for 120minutes to establish the rat model of myocardial MIRI.Forty five rats were randomly divided into sham-opera-tion group,MIRI group and EPO group(rHuEPO 3000U/kg).ECG was traced continuously to record the arrhythmia caused by reperfusion.The levds of serum MDA,CK and LDH were detected at reperfusion for 120min.Results The arrhythmia score in MIRI group and EPO group were significantly hisher than those in sham-operation group(P<0.05).Ventrlcular mchycardia and the duration of ventricular fibrillation in EPO group were significantly lower than those in MIRI group(P<0.05).The levels of serum MDA,CK and LDH in MIRI group and EPO group were signifi-cantly higher than those in sham-operation group(P<0.05).EPO group were significantly lower than MIRI group(P<0.05).Conclussion EPO had protective effects on myocardial MIRI and the mechanism might be related to anti-oxidative stress.

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